We have discovered a collection of ginseng-based steroids that can increase muscle fiber regeneration, mediated by potentiation of inflammatory mechanism without observable increased basal leukocyte infiltration in skeletal muscle. It is generally consider increasing oxidative stress as an unwanted metabolic outcome. However, we have found that supplementation of prolonged ginseng-based steroids results in elevated ROS level yet leads to anti-inflammatory action against a muscle-damaging exercise. Among these ginseng-based steroids, Rg1 appears to be the only identified molecule, which can stabilize the cellular lipid structure against high-intensity exercise in humans. Lipid component in cells is vulnerable to reactive oxygen species inevitably generated during exercise. This is a potential factor that lowers cell function and therefore causes fatigue. High intensity endurance performance (80% VO2max) is significantly improved by pre-exercise Rg1 supplementation. We are proud that such discovery has contributed in part to Amnat Ruenroeng’s success in IBF flyweight boxing world title in Macau 2015 against the Olympic Gold Medalist.
Professor Chia-Hua Kuo
University of Taipei, Taipei, Taiwan